Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 translocation events, and 4 activation/inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from 'NetPath', a repository for signaling pathways. We believe that this will help in the identification of potential therapeutic targets in IL-11-associated disorders. © 2013 Informa Healthcare USA, Inc.
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Lab Balakrishnan, Soman, Sa, Patil, Y. Bc, Advani, Ja, Thomas, J. Kad, Desai, D. Vc, Kulkarni-Kale, Uc, Harsha, H. Ca, Prasad, T. S. Kad, Raju, Ra, Pandey, Ae, Dimitriadis, Efg, and Chatterjee, Aa, “IL-11/IL11RA receptor mediated signaling: A web accessible knowledgebase”, Cell Communication and Adhesion, vol. 20, pp. 81-86, 2013.