Publication Type:

Journal Article

Source:

Indian Journal of Pharmaceutical Sciences, Volume 81, Issue 4, p.729-736 (2019)

URL:

https://www.ijpsonline.com/articles/incidence-and-predictors-of-contrastinduced-nephropathy-in-patients-undergoing-percutaneous-coronary-interventions-at-an-indian-te-3674.html

Keywords:

Contrast-induced nephropathy, Mehran risk score, Percutaneous Coronary Intervention, Sensitivity, specificity

Abstract:

This investigation is aimed to assess the incidence and possible risk factors of contrast-induced nephropathy and also the utility of Mehran risk score for prediction of contrast-induced nephropathy in patients undergoing percutaneous coronary interventions. A cross-sectional observational study was conducted on 480 patients who underwent percutaneous coronary interventions. Patients with and without contrast-induced nephropathy were evaluated to recognize the predictive factors of contrast-induced nephropathy and explored the benefit of Mehran’s risk score for prediction of contrast-induced nephropathy using receiver operating characteristics curve, Youden’s index and a likelihood ratio test. The incidence of contrast-induced nephropathy was 5.2 % (95 % confidence interval- 4.75¬ to 5.65). The associated risk factors were diabetes mellitus, hypertension, age >75 years and contrast volume ≥100 ml (p>0.001). Multivariate analysis identified age >75 years and hypertension as independent risk factors. Low Mehran risk category (score <5) patients had a higher occurrence (56 %) of contrast-induced nephropathy compared to other Mehran risk groups. Mehran risk scoring had high sensitivity (63.1 %) and low specificity (44 %) which was affirmed by Youden’s index (0.071) and an area under the receiver operating characteristics curve of 0.592. Contrast-induced nephropathy is a possible risk factor for all patients undergoing percutaneous coronary interventions. Contrast volume ≥100 ml, age >75 years, diabetes mellitus and hypertension were the predictors of contrast-induced nephropathy. Mehran risk score appeared irrelevant in stratifying the risk of contrast-induced nephropathy in patients undergoing percutaneous coronary interventions.

Cite this Research Publication

M. Sasidharan, Emmanuel James, and Menon, J. C., “Incidence and Predictors of Contrast-induced Nephropathy in Patients Undergoing Percutaneous Coronary Interventions at an Indian Tertiary Care Center”, Indian Journal of Pharmaceutical Sciences, vol. 81, no. 4, pp. 729-736, 2019.