Publication Type:

Journal Article


Head and Neck, Volume 30, Number 11, p.1422-1430 (2008)



Adjuvant, adolescent, adult, aged, analysis of variance, Antineoplastic Combined Chemotherapy Protocols, article, bone necrosis, Bone Plates, cancer chemotherapy, cancer radiotherapy, Carcinoma, Chemotherapy, child, cisplatin, controlled study, dosage schedule comparison, female, Follow-Up Studies, Fracture Fixation, Hospitals, human, Humans, Internal, major clinical study, male, mandible, mandible reconstruction, middle aged, mouth cancer, Mouth Neoplasms, multivariate analysis, Odds Ratio, Oral Surgical Procedures, plate fixation, postoperative care, postoperative complication, Postoperative Complications, postoperative period, Preschool, priority journal, Radiotherapy, Reconstructive Surgical Procedures, Retrospective Studies, Risk Factors, skin fistula, Surgical Flaps, Teaching, treatment outcome


Background. Plate osteosynthesis is a widely used technique in head and neck reconstructive surgery. The objective of this study was to determine whether postoperative chemoradiotherapy, which was recently introduced for high-risk head and neck cancer, affects plate and osteosynthesis related complications. Methods. Fifty-two consecutive patients, who had undergone plate osteosynthesis for mandibular reconstruction between October 2003 and September 2006, were included in the study. The patients were divided into 3 groups: (1) surgery alone (n = 19), (2) surgery with postoperative radiotherapy (n = 14), and (3) surgery with concurrent chemoradiotherapy (n = 19). Outcome measures included any bone or plate related complications. Results. The plate and osteosynthesis related complications occurred in 10.5% of patients in surgery-alone group, 28.6% in surgery with postoperative radiation group, and 63.2% in surgery with postoperative concurrent chemoradiotherapy group. The differences in the complication rates among these 3 groups were statistically significant (p = .003). In univariate analysis, postoperative radiation (p = .007) and concurrent chemotherapy (p = .003) were found to be significantly associated with complications. In multivariate analysis, only concurrent chemotherapy was found to be statistically significant (p = .002) with odds ratio of 7.72. Conclusion. Postoperative concurrent chemoradiotherapy significantly increases plate and osteosynthesis related complications in oral cancer. © 2008 Wiley Periodicals, Inc.


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Cite this Research Publication

Ra Sharan, Iyer, Sa, Chatni, S. Sa, Samuel, Jb, Sundaram, K. Rc, Cohen, R. Fbd, Pavithran, Ke, and Kuriakose, M. Aa, “Increased plate and osteosynthesis related complications associated with postoperative concurrent chemoradiotherapy in oral cancer”, Head and Neck, vol. 30, pp. 1422-1430, 2008.