Infusion chemotherapy with cisplatinum and fluorouracil in the treatment of locally-advanced and metastatic gallbladder cancer
Publication Type:Journal Article
Source:Journal of Cancer Research and Therapeutics, Volume 4, Number 4, p.151-155 (2008)
Keywords:adult, advanced cancer, aged, Antineoplastic Combined Chemotherapy Protocols, article, capecitabine, cisplatin, combination chemotherapy, Deoxycytidine, diarrhea, drug efficacy, drug infusion, drug tolerability, febrile neutropenia, female, fluorouracil, folinic acid, gallbladder cancer, Gallbladder Neoplasms, gemcitabine, human, Humans, inoperable cancer, kidney failure, major clinical study, male, metastasis, middle aged, mitomycin, multiple cycle treatment, myocarditis, Neoplasm Metastasis, neutropenia, overall survival, paclitaxel, Prognosis, Prospective Studies, treatment outcome, vomiting
Background: Gallbladder cancer (GBC) has a poor prognosis. Chemotherapy is traditionally considered to be ineffective. The goal of the current study was to evaluate the efficacy of infusional 5-fluorouracil (5-FU) and cisplatinum (CDDP) in patients with inoperable GBC. Materials and Methods: A total of 65 patients with inoperable GBC received palliative chemotherapy with CDDP and 5-FU. All the patients had clinically measurable disease as well as adequate bone marrow, hepatic, and renal function. Response was assessed after three cycles of chemotherapy. Results: A total of 19 patients had locally advanced unresectable cancer and 46 patients had metastatic cancer. There were 39 females and 26 males, with a median age of 50 years. A total of 212 chemotherapy cycles were administered to the patients. Response evaluation after three cycles of chemotherapy revealed complete response in five patients [7.69%; 95% confidence interval (95% CI): 2.87-16.22], partial response in 17 patients (26.15%; 95% CI: 16.57-37.81), stabilization of disease in 9 patients (13.85%; 95% CI: 6.96-23.88), and progression in 21 patients (32.30%; 95% CI: 21.80-44.35). At 6 months 44.6% patients were alive and 18.5% patients were alive at 12 months. The median overall survival was 5.7 months and the median time to disease progression was 3.1 months. This chemotherapy combination was well tolerated. There were no chemotherapy-related deaths. Conclusions: Infusion chemotherapy with CDDP and 5-FU appears to have a fair amount of activity in patients of inoperable GBC, with acceptable toxicity. Tumor shrinkage following treatment with this regimen enabled surgical resection in two patients. We believe that this promising combination must be tested against gemcitabine-based combinations in patients with inoperable GBC.
cited By (since 1996)8
Cite this Research Publication
Related Research Publications
- Surgical treatment pattern and outcomes in epithelial ovarian cancer patients from a cancer institute in Kerala, India.
- Combinatorial anticancer effects of curcumin and 5-fluorouracil loaded thiolated chitosan nanoparticles towards colon cancer treatment
- A pilot study to assess the feasibility of evaluation of markers of response to chemotherapy at one day & 21 days after first cycle of chemotherapy in carcinoma of breast: A prospective non-randomized observational study
- Correlation of clinico-pathologic and radiologic parameters of response to neoadjuvant chemotherapy in breast cancer
- A Randomized Double-Blind Placebo-Controlled Phase IIB Trial of Curcumin in Oral Leukoplakia.