Publication Type:

Book Chapter

Source:

Notch Signaling in Embryology and Cancer: Molecular Biology of Notch Signaling, Springer International Publishing, Volume 1227, Cham, p.131–144 (2020)

ISBN:

9783030364229

URL:

https://doi.org/10.1007/978-3-030-36422-9_9

Abstract:

Notch plays multiple roles both in development and in adult tissue homeostasis. Notch was first identified in Drosophila in which it has then been extensively studied. Among the flag-ship Notch functions we could mention its capacity to keep precursor and stem cells in a nondifferentiated state but also its ability to activate cell proliferation that in some contexts could led to cancer. In general, both these functions involve, canonical, ligand-dependent Notch activation. However, a ligand-independent Notch activation has also been described in a few cellular contexts. Here, we focus on one of such contexts, Drosophila muscle stem cells, called AMPs, and discuss how insulin-dependent noncanonical activation of Notch pushes quiescent AMPs to proliferation.

Cite this Research Publication

Dr. Rajaguru Aradhya and Jagla, K., “Insulin-dependent Non-canonical Activation of Notch in Drosophila: A Story of Notch-Induced Muscle Stem Cell Proliferation”, in Notch Signaling in Embryology and Cancer: Molecular Biology of Notch Signaling, vol. 1227, J. Reichrath and Reichrath, S., Eds. Cham: Springer International Publishing, 2020, pp. 131–144.