Publication Type:

Journal Article

Source:

Open Medicinal Chemistry Journal, Bentham Science Publishers B.V., Volume 11, p.3-25 (2017)

URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040054252&doi=10.2174%2f1874104501711010222&partnerID=40&md5=5a231f986f282295f6934d4d11ea9860

Keywords:

analytical parameters, article, calibration, drug compatibility, drug content, drug delivery system, drug formulation, drug penetration, drug release, drug solubility, drug stability, flow kinetics, gel strength, gelling time, histopathology, human, human tissue, infrared spectroscopy, intranasal insitu gelling system, ion activated mucoadhesive polymer, lamotrigine, melting point, mucoadhesion strength, mucoadhesion time, partition coefficient, pH, physical chemistry, polymer, priority journal, scanning electron microscopy, spreadability, syringeability, tablet property, transmission electron microscopy, unclassified drug, viscosity, X ray diffraction

Abstract:

<p>Background: A novel drug delivery system for treating acute epileptic condition. Objective: To develop an intranasal mucoadhesive formulation of Lamotrigine (LTG) loaded insitu gel, for the treatment of epilepsy to avoid possible side effects and first pass metabolism associated with conventional treatment. Method: Lamotrigine was loaded into different polymeric solutions of gellan and xanthan gum. Results: All formulations subjected to various evaluation studies were within their acceptable limits. The pH of formulation ranges between 5.8 ±.001 to 6.8 ±.005 indicating that no mucosal irritation is expected as pH was in acceptable range. Invitro drug release from the mucoadhesive insitu gel formulations showed immediate drug release pattern with a maximum drug release of 97.02 ±0.54% for optimized G5 formulation within 20min. Exvivo permeation studies of optimized formulation G5 and control formulation was estimated. Exvivo permeation studies of G5 insitu formulation done for a period of 12 h resulted in slow, sustained release and greater permeability significance(P &lt;0.05) through nasal mucosa when compared to control. Histopathological studies showed that G5 formulation was safer for nasal administration without any irritation. The stability studies indicated that gels were stable over 45 days in refrigerated condition (4±2°C). Conclusion: The intranasal insitu gelling system is a promising novel drug delivery system for an antiepileptic drug lamotrigine which could enhance nasal residence time with increased viscosity and mucoadhesive character and provided better release profile of drug for treating acute epileptic conditions. © 2017 Paul et al.</p>

Notes:

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Cite this Research Publication

A. Paul, Fathima, K. M., and Nair, S. C., “Intra nasal insitu gelling system of lamotrigine using ion activated mucoadhesive polymer”, Open Medicinal Chemistry Journal, vol. 11, pp. 3-25, 2017.

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