Intraperiodontal pocket: An ideal route for local antimicrobial drug delivery
Publication Type:Journal Article
Source:Journal of Advanced Pharmaceutical Technology and Research, Volume 3, Number 1, p.9-15 (2012)
Keywords:antibiotic agent, antibiotic therapy, bacteriology, biocompatibility, chlorhexidine gluconate, chronic periodontitis, clinical effectiveness, controlled drug release, cost benefit analysis, doxycycline hyclate, drug absorption, drug blood level, drug delivery system, drug effect, drug efficacy, drug potency, drug safety, drug solubility, drug stability, first pass effect, gingiva disease, gingivitis, Gram negative infection, human, minimum inhibitory concentration, minocycline, nonhuman, patient compliance, periodontal pocket, periodontitis, placebo, polymer, polymerization, preventive dentistry, priority journal, reservoir, review, symptomatology, tetracycline, treatment duration, treatment planning
Periodontal pockets act as a natural reservoir filled with gingival crevicular fluid for the controlled release delivery of antimicrobials directly. This article reflects the present status of nonsurgical controlled local intrapocket delivery of antimicrobials in the treatment of periodontitis. These sites have specialty in terms of anatomy, permeability, and their ability to retain a delivery system for a desired length of time. A number of antimicrobial products and the composition of the delivery systems, its use, clinical results, and their release are summarized. The goal in using an intrapocket device for the delivery of an antimicrobial agent is the achievement and maintenance of therapeutic drug concentration for the desired period of time. Novel controlled drug delivery system are capable of improving patient compliance as well as therapeutic efficacy with precise control of the rate by which a particular drug dosage is released from a delivery system without the need for frequent administration. These are considered superior drug delivery system because of low cost, greater stability, non-toxicity, biocompatibility, non-immunogenicity, and are biodegradable in nature. This review also focus on the importance and ideal features of periodontal pockets as a drug delivery platform for designing a suitable dosage form along with its potential advantage and limitations. The microbes in the periodontal pocket could destroy periodontal tissues, and a complete knowledge of these as well as an ideal treatment strategy could be helpful in treating this disease.
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