Publication Type:

Journal Article

Source:

PLoS ONE, Volume 6, Number 7 (2011)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-79960453750&partnerID=40&md5=4788c492578559aba37c59179548eb90

Keywords:

action potential, Action Potentials, algorithm, Algorithms, animal, Animals, article, biological model, Blind Source Separation algorithm, brain cortex, cell aggregation, cell granule, cerebellar mossy fiber, cerebellum, compartment model, Computer simulation, controlled study, Cytology, Cytoplasmic Granules, dendrite, granule cell, Hippocampal, hippocampal mossy fiber, in vivo study, local field potential, long term depression, long term potentiation, Long-Term Potentiation, Long-Term Synaptic Depression, Models, Mossy Fibers, nerve cell plasticity, nerve fiber, nerve tract, Neural Pathways, Neurological, nonhuman, physiology, prediction, rat, Rats, Rattus, sensory nerve, sodium current, sodium ion, somatosensory cortex, spike wave, tactile stimulation, thalamus ventral nucleus, trigeminal nucleus

Abstract:

Local field-potentials (LFPs) are generated by neuronal ensembles and contain information about the activity of single neurons. Here, the LFPs of the cerebellar granular layer and their changes during long-term synaptic plasticity (LTP and LTD) were recorded in response to punctate facial stimulation in the rat in vivo. The LFP comprised a trigeminal (T) and a cortical (C) wave. T and C, which derived from independent granule cell clusters, co-varied during LTP and LTD. To extract information about the underlying cellular activities, the LFP was reconstructed using a repetitive convolution (ReConv) of the extracellular potential generated by a detailed multicompartmental model of the granule cell. The mossy fiber input patterns were determined using a Blind Source Separation (BSS) algorithm. The major component of the LFP was generated by the granule cell spike Na + current, which caused a powerful sink in the axon initial segment with the source located in the soma and dendrites. Reproducing the LFP changes observed during LTP and LTD required modifications in both release probability and intrinsic excitability at the mossy fiber-granule cells relay. Synaptic plasticity and Golgi cell feed-forward inhibition proved critical for controlling the percentage of active granule cells, which was 11% in standard conditions but ranged from 3% during LTD to 21% during LTP and raised over 50% when inhibition was reduced. The emerging picture is that of independent (but neighboring) trigeminal and cortical channels, in which synaptic plasticity and feed-forward inhibition effectively regulate the number of discharging granule cells and emitted spikes generating "dense" activity clusters in the cerebellar granular layer. © 2011 Diwakar et al.

Notes:

cited By (since 1996)6

Cite this Research Publication

S. Dr. Diwakar, Lombardo, P., Solinas, S., Naldi, G., and D'Angelo, E., “Local field potential modeling predicts dense activation in cerebellar granule cells clusters under LTP and LTD control”, PLoS ONE, vol. 6, 2011.