Publication Type:

Journal Article

Source:

Materials Letters, Volume 160, p.335 - 338 (2015)

URL:

http://www.sciencedirect.com/science/article/pii/S0167577X15303505

Keywords:

biocompatibility, biomaterial, Mesenchymal Stem Cells, Mn doped bioactive glass, MRI, Relaxivity, Sol–gel preparation

Abstract:

Magnetic resonance imaging (MRI) is an attractive method to image biomaterial implants owing to its high spatial resolution and absence of ionizing radiation. However, most of the biomaterials lack magnetic contrast sufficient enough to be imaged in MRI. Here, we report synthesis of manganese doped nano-bioactive glass (Mn-nBG) giving bright contrast for MRI. We have optimized a room temperature method of doping nBG for efficient T1 weighted magnetic contrast. In vitro study using primary mesenchymal stem cells showed no toxicity for Mn-nBG up to a tested concentration of 100µg/ml, suggesting potential applications in cell labeling and tissue engineering.

Cite this Research Publication

N. Vadera, Anusha Ashokan, Gowd, G. S., Sajesh, K. M., Chauhan, R. P., Dr. Jayakumar Rangasamy, Shantikumar V Nair, and Dr. Manzoor K., “Manganese doped Nano-bioactive Glass for Magnetic Resonance Imaging”, Materials Letters, vol. 160, pp. 335 - 338, 2015.