Mechanism of solubility of liquisolid formulation in non volatile solvent: A review

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Abstract:

Solubility is one of the important parameter to obtain desired concentration of drug in systemic circulation. Liquisolid technique is one of the most promising techniques to achieve enhanced solubility of poorly soluble drugs. This approach is suitable for immediate or sustained release formulations and this depends upon the solubility of the drug in the non volatile solvents. Non volatile solvents enhance the solubility of water insoluble drugs by formation of micelles and act as dispersants. For immediate release liquisolid compacts, the selection of solvent is based on high drug solubility and for sustained release, solvents with least solubilising capacity is selected. The solubility of drug in non volatile solvents can be revealed by differential scanning calorimetry (DSC) and X- ray powder diffraction (XRPD). Since there are no specific non-volatile liquid vehicles used in the preparation of liquisolid compacts, different non aqueous solvents have been used as non-volatile liquid vehicles in the preparation of immediate release and sustained release liquisolid tablets with different drugs. So selection of non volatile solvent in liquisolid technique is important to obtain immediate or sustained release formulation.

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