Publication Type:



WO/2011/044328, Number PCT/US2010/051771 (2009)



A method for making microparticles having an exterior surface that includes preparing a self-assembled arrangement of microparticles; contacting the self- assembled microparticles with a patch-forming agent resulting in a microparticle/patch-forming agent assembly having proximal regions between adjacent microparticles and/or proximal regions between a microparticle and another substrate, wherein the patch-forming agent is present in the proximal region; and condensing the patch- forming agent such that a pattern of a plurality of discrete patches of patch-forming agent are formed on the exterior surfaces of the microparticles at the proximal regions. A synthetic microsphere having an exterior spherical surface, wherein the exterior spherical surface comprises a first material and a plurality of discrete, uniformly-dimensioned, patches of a second bioactive material arranged in an orderly array over more than one hemisphere of the microsphere.

Cite this Research Publication

Dr. Kaladhar Kamalasanan and R. Steven, L., “Methods to prepare patchy microparticles”, U.S. Patent PCT/US2010/0517712009.