Publication Type:

Journal Article


Materials Today: Proceedings, Volume 18, Part 7, p.3314 - 3320 (2019)



Dementia, Electrochemical sensor, Micronutrient, Pharmaceutical analysis, Vitamin B 12, Voltammetry


Electrochemical sensor for the determination of Vitamin B 12 was fabricated using a disposable pencil graphite electrode. The main highlight of this work is that without any electrode modification and analyte pre-concentration, direct electrochemical detection of Vitamin B 12 was made possible. Morphological and structural studies were incorporated. Electrochemical studies were done using cyclic voltammetry and differential pulse voltammetry. Electrochemical reduction of Vitamin B 12 was observed at -0.82 V. Sensor exhibited a linear range of 2.5-30 nM with a sensitivity of 1.96 µA/nM/cm2. The viability of the sensor towards practical use was tested in commercial Vitamin B 12 tablet.

Cite this Research Publication

R. G. Krishnan, Greeshma, S., D. Morris, S., Rameshan, S. S., and Dr. Beena S., “Morphological Studies of Disposable Graphite and its Effective utilization for Vitamin B12 Analysis in Pharmaceutical Formulations”, Materials Today: Proceedings, vol. 18, Part 7, pp. 3314 - 3320, 2019.