Publication Type:

Journal Article

Source:

International Journal of Pharmacy and Pharmaceutical Sciences, International Journal of Pharmacy and Pharmaceutical Science, Volume 6, Number 6, p.366-371 (2014)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84903895948&partnerID=40&md5=b9b6ebe26bf790e67a7d279606190ebf

Keywords:

agar diffusion, antibacterial activity, article, bacterial infection, calibration, cefixime, chitosan, drug bioavailability, drug dosage form, drug release, drug solubility, drug stability, melting point, minimum inhibitory concentration, moisture, Morphology, mucoadhesion, mucoadhesive buccal patch, nonhuman, physical chemistry, preformulation, scanning electron microscopy, spectrophotometry, Streptococcus, weight

Abstract:

Objective: The objective behind the study was to develop a bio erodible mucoadhesive buccal patch containing Cefixime trihydrate as a therapeutic agent for the treatment of bacterial infections and their evaluation. Methods: Cefixime trihydrate buccal patches were prepared by solvent casting method. Results: The formulated patches were subjected to various evaluation parameters and all the physical parameters evaluated are within the acceptable limits. The formulation F5 showed maximum release 98.1% while other formulations showed less amount of drug release in 7 hr. The in vitro antibacterial activity by agar diffusion assay demonstrated a significant antibacterial profile of the optimized patch F5 against Streptococcus species. The morphological study by Scanning electron microscopy (SEM) confirmed that the upper surface of patch containing Cefixime (F5) was rough with numerous pores inside it. The stability study proved that the formulation F5 was found to be stable. Conclusion: The prepared formulation also provides a desired antimicrobial sustained drug delivery into the systemic circulation.

Notes:

cited By (since 1996)0

Cite this Research Publication

Sreekumaran A Nair, Vidhya, K. M., Saranya, T. R., Sreelakshmy, K. R., and Nair, S. C., “Mucoadhesive buccal patch of Cefixime trihydrate using biodegradable natural polymer”, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, pp. 366-371, 2014.