Publication Type:

Journal Article

Source:

Biomaterials, Elsevier BV, Volume 35, Number 15, p.4557-4564 (2014)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84896048806&partnerID=40&md5=b9ca4366982885555b7539758adeb08b

Keywords:

Anesthetics, animal experiment, animal tissue, article, biocompatibility, Bupivacaine, DepoFoam, drug distribution, drug release, inflammation, liposome, male, mouse, Myotoxicity, neurotoxicity, nonhuman, pathology, priority journal, Rattus, sciatic nerve, Tissue, toxicity

Abstract:

Clinical translation of sustained release formulations for local anesthetics has been limited by adverse tissue reaction. Exparel™ (DepoFoam bupivacaine) is a new liposomal local anesthetic formulation whose biocompatibility near nerve tissue is not well characterized. Exparel™ injection caused sciatic nerve blockade in rats lasting 240mincompared to 120minfor 0.5% (w/v) bupivacaine HCl and 210minfor 1.31% (w/v) bupivacaine HCl (same bupivacaine content as Exparel™). On histologic sections four days after injection, median inflammation scores in the Exparel™ group (2.5 of 4) were slightly higher than in groups treated with bupivacaine solutions (score 2). Myotoxicity scores in the Exparel™ group (2.5 of 6) were similar to in the 0.5% (w/v) bupivacaine HCl group (3), but significantly less than in the 1.31% (w/v) bupivacaine HCl group (5). After two weeks, inflammation from Exparel™ (score 2 of 6) was greater than from 0.5% (w/v) bupivacaine HCl (1) and similar to that from 1.31% (w/v) bupivacaine HCl (1). Myotoxicity in all three groups was not statistically significantly different. No neurotoxicity was detected in any group. Tissue reaction to Exparel™ was similar to that of 0.5% (w/v) bupivacaine HCl. Surveillance for local tissue injury will be important during future clinical evaluation. © 2014 Elsevier Ltd.

Notes:

cited By (since 1996)1

Cite this Research Publication

J. Bab c McAlvin, Padera, R. Fd, Shankarappa, S. Ae, Reznor, Gbc, Kwon, A. Hfg, Chiang, H. Hbc, Yang, Jh, and Kohane, D. Sbc, “Multivesicular liposomal bupivacaine at the sciatic nerve”, Biomaterials, vol. 35, pp. 4557-4564, 2014.