Publication Type:

Journal Article

Source:

Indian Journal of Pharmaceutical Sciences, Medknow Publications, Volume 77, Number 1, p.8-13 (2015)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84930322746&partnerID=40&md5=b61fb8f09c34578aa7994cc2ef2aceb2

Keywords:

adolescent, adult, article, citrus fruit, clinical effectiveness, controlled study, corticosteroid, dizziness, educational status, erythema, fatigue, female, gastrointestinal irritation, headache, human, major clinical study, malaise, male, medication compliance, middle aged, nausea, patient attitude, patient compliance, polypharmacy, pruritus, psoralen, PUVA, side effect, skin irritation, skin redness, somnolence, sparfloxacin, tacrolimus, tetracycline, treatment duration, ultraviolet B radiation, vitiligo, Young Adult

Abstract:

Vitiligo is a pigmentary disorder associated with many disease conditions that necessitates multiple drug regimens, which make the treatment complicated. This stigmatic disease forces the patient to approach all system of medicines as well as alternative medicines of non proven value, which further worsens the situation. At the same time the nonadherence to the treatment reflects poor prognosis, which is misunderstood for lack of response resulting in poor faith to the medications. The aim of this work was to assess the patient compliance and the factors affecting, and to monitor the adverse effects as well as drug interactions. The study was carried out in the Institute of Applied Dermatology for a period of one year. Patient compliance was assessed using Morisky Medication Adherence Scale and found that 71% of the patients were low adherent to medications. Family support, faith in doctor, higher educational status and effectiveness of the treatment were some of the reasons for medication adherence whereas forgetfulness, feasibility, occupational problem, polypharmacy, longer duration of treatment and the feeling that the disease under is control were some of the reasons listed for nonadherence. Three adverse reactions were reported with narrow band ultraviolet B and topical tacrolimus therapy and they were categorized into possible and probable according to causality assessment by Naranjo scale. Five drug interactions were reported and the causality assessment was done using drug interaction probability scale. None of the reactions were serious or life threatening. The present study revealed the hurdles in providing safe and effective treatment to the patients and also it suggest the need of doing more research on this disease since there is a general belief that vitiligo is an incurable disease.

Notes:

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Cite this Research Publication

Sab Abraham and Raghavan, Pa, “Myths and facts about vitiligo: An epidemiological study”, Indian Journal of Pharmaceutical Sciences, vol. 77, pp. 8-13, 2015.