Publication Type:

Journal Article

Source:

Nanomedicine: Nanotechnology, Biology, and Medicine, Elsevier Inc., Volume 13, Number 2, p.667-679 (2017)

URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85010662193&doi=10.1016%2fj.nano.2016.08.013&partnerID=40&md5=c3271e9602d66c9a271b238abbe3f9a6

Keywords:

Astrocytes, drug delivery system, Microglia, Nanoparticles, Neuroglia, Neurological disorders, Neurology, Neurons, Peripheral nervous system, Targeted delivery systems, Targeted drug delivery, toxicity

Abstract:

Targeted drug delivery within the nervous system is an emerging topic of research that involves designing and developing vehicular delivery systems that have the ability to target specific neuronal and non-neuronal cell types in the central and peripheral nervous system. Drugs, genetic material, or any other payloads can be loaded onto such delivery systems and could be used to treat, prevent or manage various neurological disorders. Currently, majority of studies in this field have been concentrated around targeted delivery to neurons. However, the non-neuronal cells within the nervous system, collectively called neuroglia, have been largely ignored, though it is well known that they play a significant role in the pathophysiology of almost all neurological disorders. In this review, we present current developments in the specific area of neuroglia targeted delivery systems and highlight the use of polymeric, metallic, liposomal and other delivery systems used for this purpose. © 2016 Elsevier Inc.

Notes:

cited By 0

Cite this Research Publication

Pa Madhusudanan, Reade, Sab, and Shankarappa, S. Aa, “Neuroglia as targets for drug delivery systems: A review”, Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 13, pp. 667-679, 2017.

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