Publication Type:

Journal Article


Instrumentation and Measurement, IEEE Transactions on, Volume 58, Number 5, p.1699-1705 (2009)


arterial blood, bio-optics, biological tissues, Biomedical signal processing, Blood, Blood vessels, Bone, calibration curve, calibration-free method, curve-fitting data, light attenuation, O2, Oximetry, Oxygen, oxygen saturation, oxygen saturation measurement, photoplethysmograph, photoplethysmograph (PPG), plethysmography, pulse oximeter, sensor-dependent parameter, skin


In present-day pulse oximeters, oxygen saturation in arterial blood (SpO2) is computed by utilizing an empirical relationship extracted from a calibration curve. The calibration curve is obtained by curve-fitting data acquired from volunteers. A novel method of computation of SpO2 that does not require the use of a calibration curve is presented in this paper. Based on a model for the attenuation of light through skin, tissue, bone, and blood, suitable processing steps are identified so that the analytical expression derived for the estimation of SpO2 becomes free of not only patient but sensor-dependent parameters as well. The experimental results presented in this paper establish the efficacy of the proposed method.

Cite this Research Publication

K. A. Reddy, George, B., Mohan, N. M., and Kumar, V. J., “A Novel Calibration-Free Method of Measurement of Oxygen Saturation in Arterial Blood”, Instrumentation and Measurement, IEEE Transactions on, vol. 58, pp. 1699-1705, 2009.