Publication Type:

Journal Article

Source:

Bioorganic & Medicinal Chemistry Letters, Volume 17, Number 22, p.6107 - 6110 (2007)

URL:

http://www.sciencedirect.com/science/article/pii/S0960894X07010876

Keywords:

Serum stability

Abstract:

<p>Novel ligands, NBEA, NBPA, NETA, NE3TA, and NE3TA–Bn, were synthesized and evaluated as potential chelators of copper radioisotopes for use in targeted positron emission tomography (PET) imaging or radiation therapy. The new ligands were radiolabeled with 64Cu, and in vitro stability of the radiolabeled complexes was assessed in rat serum. Serum stability results suggest that among the ligands tested, NETA, NE3TA, and NE3TA–Bn form stable complexes with 64Cu.</p>

Cite this Research Publication

H. - S. Chong, Mhaske, S., Lin, M., Bhuniya, S., Song, H. A., Brechbiel, M. W., and Sun, X., “Novel synthetic ligands for targeted \PET\ imaging and radiotherapy of copper”, Bioorganic & Medicinal Chemistry Letters, vol. 17, pp. 6107 - 6110, 2007.

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