Osteopetrosis: A rare cause of anemia
Publication Type:Journal Article
Source:Hematology Reviews, Volume 3, Number 1, p.1-2 (2011)
Keywords:adult, Albers Schoenberg disease, anamnesis, anemia, article, autosomal dominant disorder, blood analysis, bone marrow biopsy, case report, causal attribution, clinical feature, colonoscopy, differential diagnosis, disease association, endoscopy, fluorosis, gastritis, gastrointestinal biopsy, hemoglobin, hemoglobin blood level, hemorrhoid, human, human tissue, image analysis, loose feces, lower abdominal pain, lumbar spine, male, myelofibrosis, nuclear magnetic resonance imaging, osteofluorosis, osteosclerosis, sclerosis, spastic paresis, spine radiography, weakness
Normocytic anaemia is caused either by hypoproliferation of haemopoietic tissue or increased destruction of red cells. Osteope -trosis is a rare cause of anaemia. Infantile osteopetrosis (also called malignant osteopet-rosis) is diagnosed early in life. But it is the adult osteopetrosis (also called benign osteopetrosis) which is diagnosed in late adolescence or adulthood that present as anaemia which is difficult to diagnose and treat. Approximately one half of patients are asymptomatic, and the diagnosis is made incidentally, often in late adolescence because radiologic abnormalities start appearing only in childhood. In other patients, the diagnosis is based on family history. Still other patients might present with osteomyelitis or fractures. We are presenting here an unusual case of osteopetro-sis which was referred to us for the evaluation of anaemia. © S. Sreehari et al., 2011.
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