An efficient one-pot protocol for the synthesis of multi-substituted 2-pyrone derivatives from internal alkynes and unactivated alkenes is reported. The methodology involves difunctionalization of internal alkynes by using Pd(II) as a catalyst alongwith X-Phos as ligand via 6-endo transesterification and subsequent alkenylation pathway. Notable features include simple and easily available starting materials, including a range of unactivated alkenes, reduced synthetic steps and mild reaction conditions with high efficiency.
R. S. Pathare, Sharma, S., Dr. Gopal K., Sawant, D. M., and Pardasani, R. T., “Palladium-catalyzed Convenient One-pot Synthesis of Multi-substituted 2-pyrones via Transesterification and Alkenylation of Enynoates”, Tetrahedron Letters, vol. 58, pp. 1387 - 1389, 2017.