Publication Type:

Journal Article

Source:

Tetrahedron Letters, Volume 58, Number 14, p.1387 - 1389 (2017)

URL:

http://www.sciencedirect.com/science/article/pii/S0040403917302381

Keywords:

2-Pyrones

Abstract:

An efficient one-pot protocol for the synthesis of multi-substituted 2-pyrone derivatives from internal alkynes and unactivated alkenes is reported. The methodology involves difunctionalization of internal alkynes by using Pd(II) as a catalyst alongwith X-Phos as ligand via 6-endo transesterification and subsequent alkenylation pathway. Notable features include simple and easily available starting materials, including a range of unactivated alkenes, reduced synthetic steps and mild reaction conditions with high efficiency.

Cite this Research Publication

R. S. Pathare, Sharma, S., Dr. Gopal K., Sawant, D. M., and Pardasani, R. T., “Palladium-catalyzed Convenient One-pot Synthesis of Multi-substituted 2-pyrones via Transesterification and Alkenylation of Enynoates”, Tetrahedron Letters, vol. 58, pp. 1387 - 1389, 2017.

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