Publication Type:

Journal Article


Asian Journal of Pharmaceutical and Clinical Research, Volume 6, Number SUPPL. 2, p.11-15 (2013)



1 [(4 chloro 2, 2 amino 4 (3 bromo 4, 2 amino 6 bromo 4 (1 cyano 2 ethoxy 2 oxoethyl) 4h chromene 3 carboxylic acid ethyl ester, 2 amino 7 (dimethylamino) 4 (7 methoxy 1, 2 c]chromene derivative, 2 dimethyl 2H chromen 3 yl)methylene]thiosemicabazide, 3 benzodioxol 5 yl) 4h chromene 3 carbonitrile, 4, 5, 5 dimethoxyphenyl) 7 (dimethylamino) 4h chromene 3 carbonitrile, 5 trimethoxyphenyl) 2h chromene, 6, 6 (4 hydroxybenzoyl) 2 (trifluoromethyl) 2h chromene 3 carboxylic acid, 6 chloro 2 (trifluoromethyl) 4 phenyl 2h chromene 3 carboxylic acid, 6 chloro 7 (4 nitrophenoxy) 2 (trifluoromethyl) 2h chromene 3 carboxylic acid, 6 chloro 8 methyl 2 (trifluoromethyl) 2h chromene 3 carboxylic acid, 7 dimethoxy 2, 7 dimethoxy 2 methyl 2h chromene, 7 dimethyl 3 [[methyl [2 [methyl [1 (3 trifluoromethylpheyl) 1h indol 3 ylmethyl]amino]ethyl]amino]methyl]chromen 4 one, 7 hydroxy 6 methoxy 4h chromene, 7 methoxy 2 (3, 8 dimethyl 2h chromene, acronine, alpha tocopherol, Alzheimer disease, amyotrophic lateral sclerosis, antiinflammatory activity, antineoplastic activity, apoptosis, calanone, cancer resistance, cannabichromene, chromene derivative, combretastatin A4, conrauinone A, cromakalim, degenerative disease, dihydropyrano[3, Down syndrome, drug binding site, drug cytotoxicity, drug isolation, drug protein binding, drug structure, erysenegalensein C, female infertility, gonorrhea, HIV associated dementia, human, Huntington chorea, indometacin, myoclonus, n [2 [(6 fluoro 2h chromen 8 yl)oxy]ethyl] 4 (4 methoxyphenyl)butan 1 amine, nonhuman, Parkinson disease, pharmacophore, phenylbutazone, review, schizophrenia, seselin, stomach pain, structure activity relation, tephrosin, unclassified drug, unindexed drug, uvafzlelin


Chromene (Benzopyran) was one of the privileged scaffold which appears as an important structural component in various natural products and also possess useful photochemical properties. The derivatives of benzopyran moiety can be capable of interacting with a variety of cellular targets which leads to their wide ranging biological activities such as antitumor, antihepatotoxic, antioxidant, anti-inflammatory, diuretic, anticoagulant, antispasmolytic, estrogenic, antiviral, antifungal, antimicrobial, anti-helminthic, hypothermal, vasodilatory, anti-HIV, antitubercular, herbicidal, anticonvulsant and analgesic activity. The potency of these clinically useful pharmacophore in treatment of cancer and inflammation and other activities encouraged the development of some more potent and significant compounds. The SAR studies reported that the substitution in the chromene nucleus with the specific groups increases the ability of the molecule to prevent diseases. This review is summarized to know about the different pharmacological activities of chromene nucleus with the extended knowledge about its anticancer and anti-inflammatory activity.


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Cite this Research Publication

N. Thomas and Zachariah, S. M., “Pharmacological activities of chromene derivatives: An overview”, Asian Journal of Pharmaceutical and Clinical Research, vol. 6, pp. 11-15, 2013.