Publication Type:

Journal Article

Source:

Nanomedicine: Nanotechnology, Biology, and Medicine, Volume 9, Number 6, p.818-828 (2013)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84880760990&partnerID=40&md5=757cae76a8a840de3d13709d81f4555d

Keywords:

animal experiment, animal tissue, Anti-Inflammatory Agents, Anti-inflammatory drugs, antiinflammatory agent, area under the curve, article, Biochemistry

Abstract:

The limited bioavailability and rapid clearance of the anti-inflammatory drug Ibuprofen Sodium (IbS) necessitates repeated drug administration. To address this, injectable IbS loaded PEGylated gelatin nanoparticles (PIG NPs) of size  . 200. nm and entrapment efficiency  . 70%, providing sustained release in vitro were prepared by a modified two-step desolvation process. The developed nanomedicine, containing a range of IbS concentrations up to 1. mg/mL proved to be non-toxic, hemocompatible and non-immunogenic, when tested through various in vitro assays and was reaffirmed by in vivo cytokine analysis. HPLC analysis of intravenously administered PIG NPs showed a sustained release of IbS for  . 4. days with improved bioavailability and pharmacokinetics when compared to bare IbS and IbS-loaded non-PEGylated GNPs. Histological analysis of liver and kidney revealed tissue integrity as in the control, indicating biocompatibility of PIG NPs. The results demonstrate improved plasma half-life of IbS when encapsulated within nanogelatin, thereby aiding reduction in its frequency of administration. From the Clinical Editor: In this preclinical study, improved plasma half-life of ibuprofen sodium was demonstrated when encapsulated within PEGylated gelatin nanoparticles of  200 nm size, expected to lead to reduced frequency of administration in future clinical applications. © 2013 Elsevier Inc.

Notes:

cited By 6

Cite this Research Publication

D. Narayanan, Geena, M. G., Lakshmi, H., Nair, S., Menon, D., and Koyakutty, M., “Poly-(ethylene glycol) Modified Gelatin Nanoparticles for Sustained Delivery of the Anti-inflammatory Drug Ibuprofen-Sodium: An in Vitro and in Vivo Analysis”, Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 9, pp. 818-828, 2013.