The present study was aimed to estimate the phenol content of passion fruit (Passiflora edulis) fruit and to study its antioxidant property in rabbit colon. Cold extraction of fruit was performed with 50% ethanol and fractionation was done using chloroform in a separating funnel. The phenol content was estimated by Gallic acid curve method. Oxidation was induced by incubating rabbit colon tissue substrate with Fenton’s reagent and the formed thiobarbituric acid reactive species was estimated using spectrophotometer at 535nm.The total phenolic content of fruit was found to be 102.7mg/gm. There is a gradual increase in antioxidant potency with increase in concentration from 20μg/ml. The maximum prevention (58.40%) was shown by the fruit at 50 μg/ml which is found to more effective than standard drug diclomine at the same dose (57.33 %). Imbalanced ROS production and defense mechanism by various factors may ultimately results in lipid peroxidation in colon cells which may leads to inflammatory bowel disoreders, ulcers and colitis etc,. Thiobarbituric acid- reactive substances are the byproducts of lipid peroxidation which is considered to be the clinical bio marker for of ulcerative colitis. In our study the fruit has the ability to protect from lipid peroxidation which may prevents the complications associated with IBD. © 2016, International Journal of Pharmacy and Technology.
K. J. Megha, Babu, H. C., Kutty, M. V. Sree, and S.K. Kanthlal, “Polyphenyl rich passion fruit ihnibits fenton’s regent induce lipid peroxidation in rabbit colon”, International Journal of Pharmacy and Technology, vol. 8, pp. 25158-25163, 2016.