Cancer is the major public difficulty and it is one of the top causes of death in the prosperous countries. In spite of much progress in the treatment of cancer by modern systems of medicines and therapy using synthetic drugs, search for newer natural drugs continues because of several complications like cell injury, bone marrow depression, impaired growth, sterility and hair loss that are associated with the prevalent modern cancer chemotherapy. Peperomia pellucida Linn. is widely used in the traditional medicine, belongs to the family Piperaceae. The present study involves in the investigation of various extracts of Peperomia Pellucida for its phytochemical constituents and the cytotoxic potential of P Pellucida. Qualitative phytochemical analysis of the plant extracts were done and all the extracts were screened for in vitro cytotoxic activity by MTT assay method using HEK 293 (Human Epithelial Kidney cell line), HeLa (Human cervical cancer cell line) and HePG2 (Human hepatic carcinoma cell line).It was found that the presence of phytochemicals were maximum in the methanol extract of P Pellucida when compared to other extracts and the methanol extract showed significant cytotoxic activity than all the other extracts against the above mentioned cancer cell lines while was found to be less cytotoxic against normal human kidney cells(HEK 293) displaying safety for normal cells.
Dr. Leena K. Pappachen and CHACKO, A. N. N. A. M., “Preliminary Phytochemical Screening and In-vitro Cytotoxicity Activity of Peperomia Pellucida Linn.”, Pharmacie Globale, vol. 4, p. 1, 2013.