Here we report the blood compatibility and Langmuir monolayer stability at air water interface of gold nanoparticles (GNPs) synthesized using o,o’ bis (2 amino propyl) poly ethylene glycol (M. Wt. 1900) (DAPEG) as capping agent by a one pot synthetic approach. PEGylated GNPs were synthesized with varying concentration of DAPEG using Sodium Borohydride (SBH) as a reducing agent, at room temperature. The NPs were characterized by HRTEM, Dynamic Light Scattering and UV/ Vis absorption spectroscopy. The blood compatibility of the nanoparticles in activating the blood components was investigated by haemolysis assay and platelet activation studies. Our preliminary results show that modified gold nanoparticles are more blood compatible and stabilize the lipid monolayer reflecting the possibility of tuning new hybrid materials. © Society for Biomaterials and Artificial Organs (India), 20090103-34.
C. Durgadas, Dr. Kaladhar Kamalasanan, Divya, P., Sreenivasan, K., and Sharma, C., “Preliminary studies on blood compatibility and Langmuir monolayer stability of gold nanoparticles stabilized through amino-PEG functionality”, Trends Biomater. Artif. Organs, vol. 23, no. 2, pp. 86-92, 2009.