Publication Type:

Journal Article

Source:

Journal of Biomaterials Science, Polymer Edition, Volume 22, Number 18, p.2431-2444 (2011)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-80755169741&partnerID=40&md5=9a908521a8a4c9424da62e1bc6a0778a

Keywords:

aluminum foil, Applied voltages, aqueous solution, Aqueous suspensions, article, biocompatibility, Biodegradable polymers, budesonide, cancer cell culture, cell viability, concentration response, conductance, Controlled drug delivery, controlled drug release, controlled study, dispersion, Dissolution, drug absorption, drug cytotoxicity, drug distribution, Drug encapsulation efficiency, drug formulation, Drug products, drug solubility, drug structure, electric potential, electrospray, Electrospraying, encapsulation, Encapsulation efficiency, Experimental parameters, flow rate, human, human cell, humidity, in vitro study, In-vitro, Inflammatory disorders, Inherent limitations, mitochondrion, Mono-dispersed, Nano-sized, nanobead, Nanobeads, nanoencapsulation, Nanostructured materials, Novel techniques, particle size, polycaprolactone, Polymeric nanocarriers, polysorbate 20, priority journal, Spherical nanoparticles, surface charge, surface property, surface tension, suspension, Suspensions (fluids), sustained drug release, Sustained release, sustained release preparation, temperature, viscosity, Water, zeta potential

Abstract:

Corticosteroids such as budesonide are the drugs of choice for the treatment of inflammatory disorders with an inherent limitation, viz., rapid elimination. To overcome this constraint and attain sustained release, budesonide was encapsulated in a biodegradable polymer, polycaprolactone (PCL), by DC electrospraying. By varying the experimental parameters involved in electrospraying such as applied voltage, flow rate, viscosity as well as conductivity of the polymer solution, the dimensionality of nanostructures was tuned from 1-D nanofibers to spherical nanoparticles. By adopting this rapid and viable method of DC electrospraying, we successfully prepared aqueous suspensions of nearly monodispersed, nano-sized drug encapsulated PCL. Drug encapsulation efficiency, in vitro drug release as well as biocompatibility studies of budesonide-loaded PCL nanobeads were carried out. The cytocompatible nanobeads prepared by electrospraying exhibited good encapsulation efficiency (approx. 75%), with controlled drug release enabled by the dissolution of the polymer. Our results demonstrate the potential of this novel technique of electrospraying in developing efficient drug encapsulated polymeric nanocarriers possessing sustained drug release profile. © 2011 Koninklijke Brill NV, Leiden.

Notes:

cited By (since 1996)3

Cite this Research Publication

B. T. Midhun, Shalumon, K. T., Manzoor, K., Jayakumar, R., Shantikumar V. Nair, and Deepthy, M., “Preparation of budesonide-loaded polycaprolactone nanobeads by electrospraying for controlled drug release”, Journal of Biomaterials Science, Polymer Edition, vol. 22, pp. 2431-2444, 2011.