Publication Type:

Journal Article


Carbohydrate Polymers, Volume 97, Number 2, p.469-474 (2013)



Anti-bacterial activity, Bacteria, Biomedical applications, chitin, Cytocompatibility, Medical applications, Nanogels, Nanoparticles, Nanostructured materials, Nickel, Nickel nanoparticles


In this work, we developed 120-150 nm sized nickel nanoparticles loaded chitin nanogels (Ni-Chitin NGs) by regeneration chemistry approach to investigate and determine its cytocompatibility and antibacterial activity against Staphylococcus aureus. The nickel nanoparticles were prepared by hydrothermal method. The prepared Ni-Chitin NGs were well characterized by SEM, FTIR, TG/DTA/DTG and XRD and the in vitro cytocompatibility was tested on A549 and L929 cells which showed that they are completely non-toxic. Ni-Chitin NGs showed better toxicity to the bacterial strains when compared to previous study with other nanoparticles using serial dilution method. The rhodamine labeled-Ni-Chitin NGs showed cellular localization on both L929 and A549 cells without perturbing their cellular constituents. These studies showed that the Ni-Chitin NGs could be used for various applications in biomedical filed. © 2013 Elsevier Ltd. All rights reserved.


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Cite this Research Publication

A. N. Kumar, N. Rejinold, S., Anjali, P., Balakrishnan, A., R.a Biswas, and Jayakumar, R., “Preparation of chitin nanogels containing nickel nanoparticles”, Carbohydrate Polymers, vol. 97, pp. 469-474, 2013.