Publication Type:

Journal Article


Carbohydrate Polymers, Volume 80, Number 3, p.833 - 838 (2010)



chitosan, Controlled drug delivery, emulsion, Lamivudine drug, Nanoparticles, Poly(lactic acid)


Poly(lactic acid) (PLA)/chitosan (CS) nanoparticles were prepared by emulsion method for anti-HIV drug delivery applications. The prepared PLA/CS nanoparticles were characterized using DLS, SEM, and FTIR. The hydrophilic antiretroviral drug Lamivudine was loaded into PLA/CS nanoparticles. The encapsulation efficiency and in-vitro drug release behaviour of drug loaded PLA/CS nanoparticles were studied using UV spectrophotometer. In addition, the cytotoxicity of the PLA/CS nanoparticles using MTT assay was also studied. The in-vitro drug release studies showed that drug release rate was lower in the acidic pH when compared to alkaline pH. This may due to repulsion between H+ ions and cationic groups present in the polymeric nanoparticles. Drug release rate was found to be higher in the 6% drug loaded formulation when compared to 3% drug loaded formulation. These results indicated that the PLA/CS nanoparticles are a promising carrier system for controlled delivery of anti-HIV drugs.


cited By (since 1996)26

Cite this Research Publication

A. Dev, Binulal, N. S., Anitha, A., Nair, S. V., Furuike, T., Tamura, H., and Dr. Jayakumar Rangasamy, “Preparation of Poly(lactic acid)/chitosan Nanoparticles for Anti-HIV Drug Delivery Applications”, Carbohydrate Polymers, vol. 80, pp. 833 - 838, 2010.