Presence of a receptor for the active component of iscador in ascites fluid of tumour bearing mice
Publication Type:Journal Article
Source:Cancer Letters, Volume 48, Number 3, p.223-227 (1989)
Keywords:animal, animal cell, animal experiment, Animalia, Antineoplastic Agents, article, ascites fluid, Ascitic Fluid, Cytology, drug, drug receptor, ehrlich ascites tumor, Experimental, female, Mice, mouse, Neoplasms, nonhuman, Phytogenic, Plant Extracts, priority journal, Receptors, Viscum album
Tumour bearing mice exhibit a specific "receptor" in the ascites fluid which binds with the active component isolated from Iscador. This "receptor" was found to be a protein which inhibited the cytotoxicity of Iscador and its isolated active component at low concentration. The receptor protein was also found in the sonicates of tumour cells which are susceptible to the action of Iscador but not in lymphocytes which were not susceptible to Iscador or its isolated active component. The receptor was separated on a Sephadex G-50 column. Activity was lost upon heat denaturation and dialysis. © 1989.
cited By 1
Cite this Research Publication
Related Research Publications
- Isolation and identification of a tumour reducing component from mistletoe extract (Iscador)
- Effect of a preparation from Viscum album on tumor development in vitro and in mice
- D-Aminoacid Oxidase-Fe2O3 Nanoparticle Complex Mediated Antitumor Activity in Swiss Albino Mice
- Augmentation of murine natural killer cell and antibody dependent cellular cytotoxicity activities by Phyllanthus emblica, a new immunomodulator
- Thermo-responsive fibrinogen nanogels: a viable thermo-responsive drug delivery agent for breast cancer therapy?