Publication Type:

Journal Article

Source:

Current Medicinal Chemistry, Bentham Science Publishers B.V., Volume 24, Number 31, p.3413-3432 (2017)

URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040027415&doi=10.2174%2f0929867324666170724142641&partnerID=40&md5=6639c2de741d778c0b3cd55051b0d908

Keywords:

angiogenesis, angiogenesis modulator, angiogenic factor, animal, Animals, antiangiogenic therapy, beta amyrin, bibliographic database, cathelicidin antimicrobial peptide LL 37, celecoxib, chemistry, Comb1 peptide, coronary artery disease, deferoxamine, dimethyloxalylglycine, Drug effects, fibroblast growth factor, Fibroblast Growth Factors, fucoidin, GHK peptide, Growth factor, heparin, human, Humans, Intercellular Signaling Peptides and Proteins, laminin, lanthanide, mimosine, molecular library, nanomaterial, Neovascularization, neovascularization (pathology), nonhuman, PAB2 1c protein, pathology, peptide, Peptides, pharmacology, Physiologic, polysaccharide, Polysaccharides, pr 39, QHREDGS peptide, qualitative analysis, revascularization, review, signal peptide, Small Molecule Libraries, therapeutic use, UN3 peptide, unclassified drug, ursolic acid, Vascular Endothelial Growth Factors, vasculotide, vasculotropin, vasculotropin 165, vasculotropin 81 91

Abstract:

Background: Therapeutic angiogenesis is a clinical intervention for controlled stimulation and augmentation of neovascularisation in ischemic tissues. Conventional therapeutic techniques involve proangiogenic factor based induction of host tissue angiogenesis. In this review, we provide a holistic idea about therapeutic angiogenesis while specifically highlighting the role of proangiogenic factors as growth factors, peptides, small molecules and polysaccharides in tissue neovascularisation. Methods: A detailed search of peer-reviewed literature was carried out with prime focus on therapeutic angiogenesis and proangiogenic factors. The content of each literature reviewed in this paper was qualitatively analysed for particulars and relevance to the subject of study. This work has been distributed under four broad titles, namely, proangiogenic growth factors, peptides, small molecules and polysaccharides. Also, recent developments pertaining to proangiogenic factors for therapeutic angiogenesis have been detailed. Results: A total of 244 literatures have been reviewed from the bibliographic database to present a conceptual understanding about the importance of proangiogenic factors in revascularisation of ischemic tissues. Conclusion: This review focuses on importance of various proangiogenic factors, with reference to therapeutic angiogenesis. Thorough analysis of clinical data reveals the dearth of a defined system for proangiogenic growth factor delivery. Designing of a biomaterial based paradigm for growth factor therapy, might help in enhancing clinical translation of therapeutic angiogenesis.

Notes:

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Cite this Research Publication

V. Selvaprithviraj, Sankar, D., Sivashanmugam, A., Srinivasan, S., and Dr. Jayakumar Rangasamy, “Pro-angiogenic Molecules for Therapeutic Angiogenesis”, Current Medicinal Chemistry, vol. 24, pp. 3413-3432, 2017.

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