Publication Type:

Journal Article

Source:

Pharmanest- An International Journal of Advances in Pharmaceutical Sciences, Volume 8, Issue 3 (2011)

URL:

https://www.pharmanest.net/view.php?id=66

Keywords:

Enzymes, Flacourtia indica, hepatoprotective, methotrexate

Abstract:

The acute toxicity studies of petroleum ether extract of aerial parts of Flacourtia indica (Burm.f.) Merr. was done in albino mice. The extract up to a dose of 1750 mg/ kg was tolerated in mice. The extract was further evaluated for hepatoprotective effect in methotrexate (20mg/kg ip for 1 day) induced hepatotoxicity in rat models. MTX induced hepatotoxicity characterized by significant alterations in marker enzymes for liver function and oxidative stress were observed. The Flacourtia extract treatment in a dose of 350mg/kg orally for 5 days significantly improved the level of marker enzymes for liver function and oxidative stress; which was evident in histopathology also where a relative degree of reversal of methotrexate induced necrosis was observed.

Cite this Research Publication

J. Varkey and Thomas, J., “Protective Effect of Flacourtia Indica (Burm.F) Merr. in Methotrexate Induced Hepatotoxicity”, Pharmanest- An International Journal of Advances in Pharmaceutical Sciences, vol. 8, no. 3, 2011.

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