Curcumin, derived from the rhizome Curcuma longa, is a natural anti-cancer agent and has been shown to inhibit proliferation and survival of tumor cells. Although the anti-cancer effects of curcumin are well established, detailed understanding of the signaling pathways altered by curcumin is still lacking. In this study, we carried out SILAC-based quantitative proteomic analysis of a HNSCC cell line (CAL 27) to investigate tyrosine signaling in response to curcumin.
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L. Dhevi Naga Selvan, Kaviyil, J. Embekkat, Nirujogi, R. Sekhar, Muthusamy, B., Puttamallesh, V. N., Subbannayya, T., Syed, N., Radhakrishnan, A., Kelkar, D. S., Ahmad, S., and Dr. Bipin G. Nair, “Proteogenomic analysis of pathogenic yeast Cryptococcus neoformans using high resolution mass spectrometry”, Clinical proteomics, vol. 11, no. 1, p. 1, 2014.