Curcumin, derived from the rhizome Curcuma longa, is a natural anti-cancer agent and has been shown to inhibit proliferation and survival of tumor cells. Although the anti-cancer effects of curcumin are well established, detailed understanding of the signaling pathways altered by curcumin is still lacking. In this study, we carried out SILAC-based quantitative proteomic analysis of a HNSCC cell line (CAL 27) to investigate tyrosine signaling in response to curcumin.
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Lakshmi Dhevi Naga Selvan, Jyothi Embekkat Kaviyil, Raja Sekhar Nirujogi, Babylakshmi Muthusamy, Vinuth N Puttamallesh, Tejaswini Subbannayya, Nazia Syed, Aneesha Radhakrishnan, Dhanashree S Kelkar, Sartaj Ahmad, and Dr. Bipin G. Nair, “Proteogenomic analysis of pathogenic yeast Cryptococcus neoformans using high resolution mass spectrometry”, Clinical proteomics, vol. 11, no. 1, p. 1, 2014.