Publication Type:

Journal Article

Source:

Materials Today: Proceedings, Volume 5, Number 9, Part 3, p.17812 - 17819 (2018)

URL:

http://www.sciencedirect.com/science/article/pii/S2214785318312161

Keywords:

clopidogrel, clopidogrel-tetraidobismuthate, potentiometry, PVC membrane sensor

Abstract:

This paper describes the fabrication of potentiometric PVC membrane for clopidogrel bisulphate and its successful utilization in the determination clopidogrel from clopilet tablet. Effect of PVC membrane matrix were studied and optimized membrane composition which ensued a Nernstian slope of 58.83±0.340mV/decade was found to be PVC 32%, ion association 3%,NaTBP 2% and DBP 63 % respectively. Sensor revealed a fast response time of 3s in the concentration range 1×10-2 -1×10-6 M with a lower detection limit of 9.12 ×10-7M. Working pH range and response time was found to be 2.0 - 4.5 and 5s respectively. Comparative studies on the various parameters that depend on the potential response of the present sensor with that of the literature reports were also included

Cite this Research Publication

A. Santhy, Dr. Beena S., P. Sankar, U., Vidya, R., and Rejithamol, R., “PVC membrane Sensor Immobilized with Clopidogrel-Tetraiodo Bismuthate for the Potentiometric Determination of Clopidogrel from Pharmaceutical Formulations”, Materials Today: Proceedings, vol. 5, pp. 17812 - 17819, 2018.