Radiotherapeutic potential of the extracts of Andrographis paniculata and Swertia chirayita
Publication Type:Journal Article
Source:Journal of Pharmacology and Toxicology, Volume 7, Number 1, p.20-28 (2012)
Keywords:alcohol, Andrographis paniculata extract, animal cell, animal experiment, animal model, animal tissue, article, bone marrow cell, cobalt teletherapy, colony formation, controlled study, DNA damage, DNA repair, DNA strand breakage, drug effect, gamma radiation, Immune system, micronucleus, mouse, nonhuman, plant extract, radiation exposure, radiation injury, radiation injury repair, radioprotective agent, reticulocyte, spleen, Swertia, Swertia chirayita, Swertia chirayita extract, unclassified drug, whole body radiation
Ethanolic extracts of two controversial medicinal plants Andrographis paniculata (ApE) and Swertia chirayita (ScE) were evaluated for its potential to enhance the repair of radiation-induced DNA damage. Post-irradiation administration of these extracts to mice resulted in faster cellular DNA repair, as revealed from the increased Cellular Repair Index (CRI) of blood leukocytes. Exposure of mice to 2 Gy whole-body gamma radiation resulted in the formation of strand breaks of cellular DNA of bone marrow cells and the unrepaired strand breaks eventually lead to the formation of micronuclei in the reticulocytes. Administration of ApE and ScE under post-irradiation conditions showed a decrease in the number of micronucleated reticulocytes. Administration of these extracts also aided in the regeneration of the immune system as revealed from the induction of endogenous spleen colony formation in mice exposed to whole body gamma radiation. Thus, the studies revealed that ethanolic extracts of A paniculata and S. chirayita abetted the revival of immune system following radiation exposure and the induction of faster and legitimate DNA repair can be the underlying mechanism. © 2012 Academic Journals Inc.
cited By (since 1996)0
Cite this Research Publication
Related Research Publications
- Alcoholic extract of Wrightia tinctoria leaves and isolates there of afford DNA protection in post irradiated Sprague Dawley rats
- Structural dynamics in DNA damage signaling and repair
- Seabuckthron (Hippophae rhamnoides L.) leaf extract ameliorates the gamma radiation mediated DNA damage and hepatic alterations.
- Gossypetin ameliorates ionizing radiation-induced oxidative stress in mice liver-a molecular approach
- DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities