Publication Type:

Journal Article


Medicinal Research Reviews, Volume n/a, Number n/a, p.1-16 (2021)



Biomaterials, cardiac surgery, hemostasis, mediastinitis, sternal healing, sternal wound infection


One of the major risks of cardiac surgery is the occurrence of infection at the sternal wound site. Sternal wound infections are primarily classified into superficial infection and deep sternal wound infection or mediastinitis. A patient is diagnosed with mediastinitis if microorganisms are present in their mediastinal tissue/fluid or with the observation of sternal wound infection during operation and with characteristic symptoms including chest pain, fever, and purulent drainage from the mediastinum. It is usually caused by Staphylococcal organisms in 75.8% of cases and the rest is caused by gram-negative bacteria. Currently, in cardiac surgery, hemostasis is achieved using electrocautery and bone wax, and the sternum is closed using wire cerclage. Several studies show that bone wax can act as a nidus for initiation of infection and the oozing blood and hematoma at the site can promote the growth of infectious organisms. Many research groups have developed different types of biomaterials and reported on the prevention of infection and healing of the sternum. These materials are reported to have both positive and negative effects. In this review, we highlight the current clinical practices undertaken to prevent infection and bleeding as well as research progress in this field and their outcomes in controlling bleeding, infection, and enhancing sternal healing.

Cite this Research Publication

A. Pradeep, Dr. Jayakumar Rangasamy, and Dr. Praveen Varma, “Recent developments in controlling sternal wound infection after cardiac surgery and measures to enhance sternal healing”, Medicinal Research Reviews, vol. n/a, pp. 1-16, 2021.