Publication Type:

Journal Article


International Journal of Pharma and Bio Sciences, Volume 4, Number 3, p.P337-P344 (2013)



aqueous solution, article, cell membrane, chemical bond, chemical structure, critical micelle concentration, drug delivery system, drug release, drug transport, hydrophobicity, infrared spectroscopy, lipid bilayer, liposome, membrane vesicle, micelle, nonviral gene delivery system, pH, phosphatidylcholine, skin conductance, skin temperature, stratum corneum, surfactant, sustained release formulation, viscosity, zeta potential


Edge activators are bilayer softening component, such as biocompatible surfactant in to which an amphiphilic drug is added to increase lipid bilayer flexibility and permeability. Many drugs having severe gastro-intestinal toxicity can be successfully delivered transdermally, but threshold barrier that is stratum corneum is the main limitation. An approach for enhancing the drug flux through the skin is by the chemical interaction of surfactant and solubilisation of the lipid in stratum corneum and enhances the penetration of many drugs. This article insights the mechanism of interaction of edge activators (surfactant) with lipid bilayer, influence of edge activators on vesicular morphology, entrapment efficiency, zeta potential, drug release, deformability, skin permeation and skin deposition. This article also reviews measurement of permeation capacity of surfactants, the application of deformable vesicles containing edge activators in transdermal delivery of various biological.


cited By (since 1996)0

Cite this Research Publication

L. Jacob and Anoop, K. R., “A review on surfactants as edge activators in ultradeformable vesicles for enhanced skin delivery”, International Journal of Pharma and Bio Sciences, vol. 4, pp. P337-P344, 2013.