Publication Type:

Journal Article

Source:

Carbohydrate Polymers, Volume 84, Number 1, p.407-416 (2011)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-78951480365&partnerID=40&md5=04f8ddf46b89b3556465802da9d3f721

Keywords:

AFM, Anti cancer saponin delivery, Cancer cell lines, Cell culture, Cell lines, chitin, chitosan, Chitosan nanoparticles, Concentration ranges, cytotoxicity, FTIR, In-vitro, Metabolites, Nanoparticles, Nanosaponin, Saponin, SEM, Specific toxicity, Sustained release, Therapeutic agents

Abstract:

In this work we developed a nanoformulation for anticancer saponin with chitosan for an enhanced and sustained release. The saponin loaded chitosan nanoparticles showed a particle size of 65 ± 7 nm. The synthesized nanoparticles were analyzed by FTIR, TG/DTA, SEM and AFM. The cytotoxicity of the nanoparticles was analyzed on L929, NIH-3T3, KB and PC3 which showed particles are non-toxic in a concentration range of 0.1-1.0 mg/ml whereas the nanosaponin showed specific toxicity on PC3 and KB cell lines. The internalization of the nanosaponin on L929 and PC3 was confirmed by Rhodamine conjugation with the nanoparticles. Our preliminary studies support that nanosaponin could be an efficient therapeutic agent for cancer. © 2010 Elsevier Ltd. All rights reserved.

Notes:

cited By (since 1996)8

Cite this Research Publication

N. Sa Rejinold, Muthunarayanan, Ma, Muthuchelian, Kb, Chennazhi, K. Pa, Nair, S. Va, and Jayakumar, Ra, “Saponin-loaded chitosan nanoparticles and their cytotoxicity to cancer cell lines in vitro”, Carbohydrate Polymers, vol. 84, pp. 407-416, 2011.