A nanoscale mimic of the extracellular matrix is electrospun from a highly tunable family of elastin-like proteins. A sequence-specific, two-step crosslinking procedure is developed to preserve the nanofiber morphology, elastin-like mechanics, and specific bioactivity. Rodent marrow stromal cells show sequence-specific adhesion on the matrices, which are imaged using label-free coherent anti-Stokes Raman scattering (CARS) microscopy. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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P. La Benitez, Sweet, J. Ab, Fink, Hc, Chennazhi, K. Pd, Nair, S. Vd, Enejder, Ac, and Heilshorn, S. Ce, “Sequence-Specific Crosslinking of Electrospun, Elastin-Like Protein Preserves Bioactivity and Native-Like Mechanics”, Advanced Healthcare Materials, vol. 2, pp. 114-118, 2013.