Serum immunoglobulins in patients with carcinoma of the oral cavity, uterine cervix and breast
Publication Type:Journal Article
Source:Cancer Immunology Immunotherapy, Springer-Verlag, Volume 22, Number 1, p.76-79 (1986)
Keywords:adult, blood and hemopoietic system, Breast, Breast Neoplasms, Carcinoma, clinical article, female, female genital system, human, Humans, immunoglobulin a, immunoglobulin blood level, immunoglobulin d, immunoglobulin E, immunoglobulin G, immunoglobulin m, Immunoglobulins, male, middle aged, mouth, Mouth Neoplasms, priority journal, Uterine Cervical Neoplasms, uterine cervix
Serum immunoglobulin levels (IgG, IgA, IgM, IgD and IgE) were estimated in 196 patients with carcinoma of the oral cavity, 172 patients with cervical cancer and 166 patients with breast cancer. The values were compared with those of 50 patients with benign lesions of the breast and cervix and 100 healthy adult controls. Only the serum IgE levels were found to be elevated in the benign group. Serum IgA, IgD and IgE levels were found to be elevated in all the three types of cancers and the levels were found to increase with clinical stage. In carcinoma of uterine cervix IgG levels were also found to be elevated. Immunoglobulins A and D returned to normal after clinical cure whereas IgE remained slightly elevated. IgD and IgE remained high in patients who had residual cancer. © 1986 Springer-Verlag.
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