Publication Type:

Journal Article

Source:

International Journal of Pharmacy and Technology, International Journal of Pharmacy and Technology, Volume 8, Number 1, p.11221-11235 (2016)

URL:

https://www.scopus.com/inward/record.url?eid=2-s2.0-84963584392&partnerID=40&md5=b12cd04d954118e9ff01651c41478b24

Abstract:

Azetidinones are four membered heterocycles with nitrogen as the heteroatom. In silico molecular modelling predicts anticancer property of azetidinone derivatives. The azetidinone derivatives can be synthesized via simple and efficient 2- step reaction. This involves production of Schiff’s base which then reacts with ketene to form azetidinone. However the reaction is highly stereo selective and the reaction carried out in this study yielded acetamide derivative. The acetamide derivative showed good activity against lung cancer cell lines. The current research work deals with an In silico approach in designing azetidinone derivatives, problems faced during the synthesis of azetidinones and the possible scheme via which the product deferred. © 2016, International Journal of Pharmacy and Technology. All rights reserved.

Notes:

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Cite this Research Publication

Dr. Subin Mary Zachariah, Ramkumar, M., George, N., Ashif, M. S., and Varghese, A., “In silico design, synthesis, characterization and in vitro evaluation of some novel anti-lung cancer molecules”, International Journal of Pharmacy and Technology, vol. 8, pp. 11221-11235, 2016.

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