Smart stimuli sensitive nanogels in cancer drug delivery and imaging: A review
Publication Type:Journal Article
Source:Current Pharmaceutical Design, Volume 19, Number 41, p.7203-7218 (2013)
Keywords:antineoplastic agent, benzophenone, biocompatibility, cancer cell, chemical binding, chitosan, cisplatin, collagen, cross linking, curcumin, cytarabine, drug delivery system, fluorouracil, glutathione, human, hyaluronic acid, hydrogel, hydrogen bond, hydrophobicity, nanocarrier, neoplasm, nonhuman, pH, polymer, polyvinyl alcohol, priority journal, protein denaturation, review, tamoxifen, temozolomide, Water, Water content
Nanogels are nanosized hydrogel particles formed by physical or chemical cross-linked polymer networks. The advantageous properties of nanogels related to the ability of retaining considerable amount of water, the biocompatibility of the polymers used, the ability to encapsulate and protect a large quantity of payload drugs within the nanogel matrix, the high stability in aqueous media, their stimuli responsively behavior potential, and the versatility in release drugs in a controlled manner make them very attractive for use in the area of drug delivery. The materials used for the preparation of nanogels ranged from natural polymers like ovalbumin, pullulan, hyaluronic acid, methacrylated chondroitin sulfate and chitosan, to synthetic polymers like poly (N-isopropylacrylamide), poly (N-isopropylacrylamide-co-acrylic acid) and poly (ethylene glycol)-b-poly (methacrylic acid). The porous nanogels have been finding application as anti-cancer drug and imaging agent reservoirs. Smart nanogels responding to external stimuli such as temperature, pH etc can be designed for diverse therapeutic and diagnostic applications. The nanogels have also been surface functionalized with specific ligands aiding in targeted drug delivery. This review focus on stimuli-sensitive, multi-responsive, magnetic and targeted nanogels providing a brief insight on the application of nanogels in cancer drug delivery and imaging in detail. © 2013 Bentham Science Publishers.
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