Publication Type:

Journal Article


International Journal of Pharmaceutical Sciences Review and Research, Volume 20, Number 2, p.127-134 (2013)



acetylsalicylic acid, amphotericin B, aprepitant, aqueous solution, cefadroxil, celecoxib, chemical modification, clathrate, clay, co solvency, complex formation, critech technology, cryo vacuum method, cryogenic technology, crystallization, cyclodextrin, cyclosporin, cyclosporin A, dissocubes, drug absorption, drug bioavailability, drug cost, drug delivery system, drug dosage form, drug efficacy, drug elimination, drug formulation, drug release, drug solubility, drug stability, drug sterility, emulsome, fenofibrate, griseofulvin, high pressure homogenization, hot melt extrusion technique, hydrophilicity, hydrotrophy, indometacin, itraconazole, ketoprofen, lipid emulsion, lipid technology, micelle, microemulsion, micronization, morphine sulfate, nanocochleate technology, nanocrystal, nanoedge technology, nanopure technology, Nanotechnology, nifedipine, oil based formulation, paclitaxel, paracetamol, particle size, patient compliance, pH, povidone, rapamycin, review, self emulsifying drug delivery system, self micro emulsifying drug delivery system, sodium chloride, solid lipid nanoparticle, solubilizer, solvent deposition, supercritical fluid process, surfactant, suspension, theophylline, thermodynamics, thermostability, unclassified drug


The most challenging task in drug development is enhancement of solubility, dissolution rate, and bioavailability of drug. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. Drug to be absorbed should be in solution form at the site of absorption. Absorption of orally administered drugs will take place only when they show fair solubility in gastric medium and such drugs show good bioavailability. Solubility and dissolution properties of drugs play an important role in the process of formulation and development. Major challenge for formulation scientist is the solubility problem which can be solved by different technological approaches during the pharmaceutical product development work. This review gives detailed information about various technologies used for enhancing solubility and dissolution of poorly soluble drugs, including nanotechnology methods for enhancing solubility to reduce the percentage of poorly soluble drug candidates eliminated from the development. Selection of this solubility enhancing method mainly depends on drug property, site of absorption and dosage form characteristics.


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Cite this Research Publication

M. N. Anjana, Joseph, J., and Nair, S. C., “Solubility enhancement methods -a promising technology for poorly water soluble drugs”, International Journal of Pharmaceutical Sciences Review and Research, vol. 20, pp. 127-134, 2013.