The stereochemistry of a sesquiterpene, 6α-hydroxy-4(14),10(15)-guaianadien-8β,12-olide (2) was established by high resolution and 2D-NMR spectroscopy. Careful analysis of the long range couplings along with vicinal spin-spin coupling constants predict a trans fusion of the lactone ring. Further information on the stereochemistry of 2 was obtained from 2D-NOESY and ROESY experiments.
P. Pradhan, Chintalwar, G. J., and Banerji, A., “Stereochemistry of a Guainolide fromCyathocline purpurea, by high resolution NMR spectroscopy”, Spect. Letts., vol. 26, p. 997, 1993.