Publication Type:

Journal Article


International Journal of Pharmaceutical Sciences Review and Research, Volume 11, Number 2, p.59-64 (2011)



amphotericin, antibacterial activity, antifungal activity, antifungal resistance, antiinfective agent, antioxidant, antioxidant activity, article, Aspergillus fumigatus, Aspergillus niger, Bacillus subtilis, Candida albicans, chloramphenicol, clotrimazole, controlled study, drug isolation, drug screening, Escherichia coli, flavanoid, in vitro study, medicinal plant, minimum inhibitory concentration, nitric oxide, nonhuman, phenol derivative, plant extract, plant leaf, Proteus vulgaris, Pseudomonas aeruginosa, quercetin, Samadera indica, Samadera indica extract, saponin derivative, Staphylococcus aureus, superoxide, tannin derivative, triterpene derivative, unclassified drug, Wound healing


Samadera indica a bitter plant widely distributed throughout India. The bitterness is due to the presence of triterpenoid such as quassinoids, this group responsible for wide variety biological activities. In the current world population, incidence of infection is increasing tremendously and hence the present study was aimed to carry out the antimicrobial activity and antioxidant activity of methanolic extract of Samadera indica, both the activities can be used to predict the wound healing activity of this extract. The methanolic extracts of Samadera indica obtained by soxhletation and was investigated for in vitro antimicrobial activity against microorganism including Gram-positive (Staphylococcus aureus, Bacillus Subtilis), Gram-negative bacteria (Pseudomonas aerueginosa, Escherichia coli and Proteus Vulgaris) and few strains of fungus such as Candida albicans, Aspergillus niger and Aspergillus fumigates. In addition, evaluated antioxidant activity and estimated total phenolic and flavanoids content. Antimicrobial studies revealed that it has significant activity against gram positive, gram negative bacteria and Candida albicans, but was resistant against Aspergillus niger and Aspergillus fumigates. All the methods of antioxidant showed a prominent antioxidant activity and were compared with Quercetin. Antioxidant activity of extracts produced increased scavenging activity in a dose dependent manner. The present study revealed the presence of antimicrobial and antioxidant activity, hence further studies could be carried out to find out the wound healing activity.


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Cite this Research Publication

Vac Viswanad, Aleykutty, N. Ab, Jaykar, Bc, Dr. Subin Mary Zachariah, and Thomas, La, “Studies on the Antimicrobial and Antioxidant Activities of the Methanolic Extracts of Samadera Indica”, International Journal of Pharmaceutical Sciences Review and Research, vol. 11, pp. 59-64, 2011.