This review emphasize on the underlying principles governing blood and tissue compatibility of biomaterials and various surface modification techniques. This could also be explored for development of functionally active nanobiomaterials. Here the role of chemical and physical stimuli, when ligands are present in the soluble or bound form in activating the biological system is extensively reviewed. Apart from that the current advances in surface modification strategies by bottom up method, or post synthetic surface modification at submicron to nano levels is discussed. Such improved surface modification strategies may have applications in drug delivery and other biomedical systems.
Dr. Kaladhar Kamalasanan and Sharma, C. P., “Surface passivation and controlled ligand supplementation of cellular activation processes–strategies for bottom up synthesis of bioactive surfaces”, Trends in Biomaterials and Artificial Organs, vol. 21, no. 1, pp. 29–62, 2007.