Publication Type:

Journal Article

Source:

International Journal of Polymeric Materials and Polymeric Biomaterials, Volume 60, Number 14, p.1123-1129 (2011)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84857863351&partnerID=40&md5=b240c433f3b7cf172bb0cb6f8ba6c7c9

Keywords:

bipolymeric blends, Crosslinked, Drug delivery, Gastrointestinal drugs, Lignosulfonic acid, Lignosulphonic acid, pH effects, pH sensitive, Sodium alginate, Sodium alginates, Solution-casting method, Strong acids, swelling, Swelling behavior, Swelling properties, Water uptake

Abstract:

A series of blends based on lignosulfonic acid (LSA) and sodium alginate (NaAlg) were prepared with varying proportions of NaAlg and LSA using a solution-casting method. The swelling /degradation behavior of blends was studied so that they can be used for gastrointestinal drug delivery. Effect of crosslinking, pH, alginate content, and treatment with strong acid on swelling properties of the blends was investigated. It was found that blends show pH-sensitive swelling and show less water uptake due to crosslinking, while crosslinking is reduced in the presence of strong acid. Thus these blends offer their strong candidature for possible use in drug delivery. Copyright © Taylor & Francis Group, LLC.

Notes:

cited By (since 1996)2

Cite this Research Publication

Dr. S. Giridhar Reddy and Dr. Akanksha Saxena Pandit, “Swelling behavior of calcium-ions crosslinked bipolymeric sodium alginate-lignosulphonic acid blends”, International Journal of Polymeric Materials and Polymeric Biomaterials, vol. 60, pp. 1123-1129, 2011.

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