Publication Type:

Journal Article

Source:

Bioorganic & Medicinal Chemistry, Volume 23, Number 13, p.3781 - 3787 (2015)

URL:

http://www.sciencedirect.com/science/article/pii/S0968089615002916

Keywords:

MMP-2 and MMP-9

Abstract:

Abstract Eleven biflavones (7a–b and 9a–i) were synthesised by a simple and efficient protocol and screened for MMP-2 and MMP-9 inhibitory activities. Amongst them, a natural product-like analog, (I-3,II-3)-biacacetin (9h) was found to be the most potent inhibitor. Molecular docking studies suggest that unlike most of the known inhibitors, 9h inhibits MMP-2 and MMP-9 through non-zinc binding interactions.

Notes:

cited By 0; Article in Press

Cite this Research Publication

P. Nanjan, Nambiar, J., Bipin G. Nair Dr., and Banerji, A., “Synthesis and Discovery of (I-3,II-3)-Biacacetin as a Novel Non-zinc Binding Inhibitor of MMP-2 and MMP-9”, Bioorganic & Medicinal Chemistry, vol. 23, pp. 3781 - 3787, 2015.