Publication Type:

Journal Article

Source:

European Journal of Medicinal Chemistry, Volume 45, Number 2, p.455 - 462 (2010)

URL:

http://www.sciencedirect.com/science/article/pii/S0223523409005285

Keywords:

Biogram

Abstract:

A series of novel CoII, NiII, CuII and ZnII complexes of 1H-pyrazole-3,5-dicarboxylic(2′-hydroxy-3′-hydrazinequinoxaline) has been prepared and characterized by the spectral and analytical techniques. CuII ion reacts with the ligand LH3 and forms the complex in one compartment of the ligand whereas, the other compartment remains free. In CoII, NiII and ZnII complexes both compartments of LH3 are involved in the coordination. DNA binding/cleavage studies were revealed the stronger binding capability of the present NiII complex, confirmed by the absorbance, viscometric and gel-electrophoresis studies. Similarly, remaining complexes do the same in the ligand field with lesser binding constants, subsequently, no complex was found to cleave the DNA. Finally, CuII complex shows growth inhibitory activity against biogram.

Cite this Research Publication

S. Budagumpi, Dr. Naveen V. Kulkarni, Kurdekar, G. S., Sathisha, M. P., and Revankar, V. K., “Synthesis and spectroscopy of CoII, NiII, CuII and ZnII complexes derived from 3,5-disubstituted-1H-pyrazole derivative: A special emphasis on DNA binding and cleavage studies”, European Journal of Medicinal Chemistry, vol. 45, pp. 455 - 462, 2010.

207
PROGRAMS
OFFERED
6
AMRITA
CAMPUSES
15
CONSTITUENT
SCHOOLS
A
GRADE BY
NAAC, MHRD
8th
RANK(INDIA):
NIRF 2018
150+
INTERNATIONAL
PARTNERS