Azaleatin- a lesser known partially methylated flavonoid, has been synthesized efficiently through MOM protection and deprotections from quercetin. The synthesized compound and closely related partially methylated flavonoids (SAR) were subjected for the investigation of α-amylase and antioxidant activities. Among the compounds tested, azaleatin was found to be best inhibitor for α-amylase with acceptable radical scavenging activity than closely related compounds. Further, in-silico modelling studies indicated that azaleatin forms hydrogen bonds with the key amino acid residues such as Gln63, Arg195 and Asp197 of α-amylase receptor. Acarbose was used as positive control for α-amylase inhibition.
Pandurangan Nanjan, Chinchu Bose, M. Sreejith, Veni C K, Anjana M Amrita, and Anjana R P., “Synthesis, bioactivities and in-silico docking studies of azaleatin-a quercetin partial methyl ether; SAR study.”, vol. 14, 2018.