Publication Type:

Journal Article

Source:

International Journal of Biological Macromolecules, Volume 42, Number 5, p.463 - 467 (2008)

URL:

http://www.sciencedirect.com/science/article/pii/S014181300800055X

Keywords:

Bioactivity, Biomaterials, chitin, Thermal studies, β-Chitin scaffolds

Abstract:

Chitin is a biopolymer and it is non-toxic, biodegradable and biocompatible. Chitin has many potential industrial applications because of its abundance, biodegradability, non-toxicity, chemical inertness. β-Chitin scaffolds were prepared by using saturated calcium chloride alcoholic solution (CaCl2·6H2O/EtOH) and then followed by dialysis with lyophilization. The prepared β-chitin scaffolds were characterized by FT-IR, scanning electron microscopy (SEM) and thermogravimetric (TGA). The preliminary bioactivity studies of β-chitin scaffolds were studied by using simulated body fluid (SBF) solution for 7, 14 and 21 days. We also immersed the β-chitin scaffolds in saturated aqueous CaCl2 and Na2HPO4 solution over 12h. After 7, 14 and 21 days, the scaffolds were characterized by SEM and FT-IR studies. The SEM studies showed that there is a calcium phosphate layer in the surface as well as in the cross-section of β-chitin scaffolds. It seems that the β-chitin scaffolds are useful in the tissue-engineering field.

Cite this Research Publication

Y. Maeda, Dr. Jayakumar Rangasamy, Nagahama, H., Furuike, T., and Tamura, H., “Synthesis, Characterization and Bioactivity Studies of Novel β-chitin Scaffolds for Tissue-engineering Applications”, International Journal of Biological Macromolecules, vol. 42, pp. 463 - 467, 2008.